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When you choose to publish with PLOS, your research makes an impact. Make your work accessible to all, without restrictions, and accelerate scientific discovery with options like preprints and published peer review that make your work more Open.

Publication Fees

PLOS employs several business models to support equitable Open Access. Most OA journals offset publication expenses – including the cost of peer review management, journal production, and online hosting and archiving – by charging a fee for each article published (APC). Our partnerships with institutions and funders aim to simplify the process for authors and reduce the burden of cost.  

Pay Invoice

Publication fees vary by journal and are payable upon article acceptance. Fees are subject to change and charged at the applicable rates effective on your submission date.




Registered Report Protocol $1,339*
Registered Report Article $775


Lab Protocols & Study Protocols $995 for protocols submitted by August 9 2021, $1,100 thereafter


All other articles $1,749

PLOS Computational Biology

All primary research articles $2,575

PLOS Genetics

All primary research articles $2,575

PLOS Neglected Tropical Diseases

All primary research articles $2,420

PLOS Pathogens

All primary research articles $2,575

PLOS Community Action Publishing took effect January 1, 2021 for PLOS Biology and PLOS Medicine. Authors will only incur fees if their institutions are not members of the journal’s collective action community. For work submitted in 2021 these non-member fees are as below:

PLOS Biology

Discovery Report $3,350
Update Articles $2,250
All other primary research articles 

PLOS Medicine

All primary research articles $4,000

all $ pricing is USD


There is growing momentum to encourage Open Access publishing through funding initiatives. Globally, authors benefit from the increasing availability of institutional, government, and foundation Open Access funds. Funding assistance for publication fees are available from many organizations, including PLOS.

Institutional Open Access Funds

Many institutions already support their researchers by setting aside financial resources to cover or reduce the cost of their Open Access publications.

We provide several models for institutions to support their authors’ work at PLOS, either through direct payment of APCs (direct-billing), Flat Fee contributions towards future publications, or Community Action Publishing membership. 

Find out if your institution is one of our Institutional Partners.

Funder Fee Support

More and more funders are encouraging researchers to publish in Open Access journals where their work can be read, and shared by all. Contact your funder directly to find out if they allow fees to be included as line items on a grant or provide specific article processing grants.

All PLOS journals comply with major funder requirements for Open Access sharing so authors don’t need to worry about their article’s eligibility.

We believe that lack of funds should not be a barrier to Open Access publication. Since our founding, PLOS has provided publication fee support to authors.

In 2019 PLOS provided $1.7 million in individual fee support to its authors, through the PLOS Global Participation Initiative (GPI) and Publication Fee Assistance Program.

PLOS Global Participation Initiative

The PLOS Global Participation Initiative (GPI) aims to lower barriers to publication based on cost for researchers around the world who may be unable, or have limited ability, to publish in Open Access journals.

Authors’ research funded primarily (50% or more of the work contained within the article) by an institution or organization from eligible low- and middle-income countries is automatically eligible for assistance. If the author’s research funder is based in a Group 1 country, PLOS will cover the entire publication fee and there will be no charge. For authors whose research funder is part of Group 2, PLOS will cover all but part of the publication fee — the remaining publication fee will be $500.

Authors must apply for GPI funding at time of manuscript submission. Authors from Group 2 countries who need additional support should apply for PLOS Publication Fee Assistance (below) instead of the PLOS GPI.

Group 1 countries Group 2 countries 

PLOS Publication Fee Assistance Program

The PLOS Publication Fee Assistance (PFA) program was created for authors unable to pay all or part of their publication fees and who can demonstrate financial need.

An author can apply for PFA when submitting an article for publication. A decision is usually sent to the author within 10 business days. PLOS considers applications on a case-by-case basis.

PLOS publication decisions are based solely on editorial criteria. Information about applications for fee assistance are not disclosed to journal editors or reviewers.


  • Authors should exhaust all alternative funding sources before applying for PFA. The application form includes questions on the availability of alternative funding sources such as the authors’ or co-authors’ institution, institutional library, government agencies and research funders. Funding disclosure information provided by authors will be used as part of the PFA application review.
  • Assistance must be formally applied for at submission. Requests made during the review process or after acceptance will not be considered. Authors cannot apply for the fee assistance by email or through direct request to journal editors.

Still have questions?   Fee Assistance FAQs

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